bellie

kepos is a microbiome health supplement brand founded in the United States, developed in partnership with the University of Chicago. The company specializes in Human Milk Oligosaccharide (HMO)-based prebiotic supplements marketed under the brand name Bellie, targeting consumers with digestive disorders including IBS, IBD, SIBO, MCAS, and leaky gut syndrome. Unlike conventional prebiotic ingredients such as chicory root inulin, FOS, or soluble corn fiber — which feed both beneficial and harmful gut bacteria indiscriminately — kepos formulates its products around HMOs, a class of complex sugars that selectively nourish Bifidobacteria, the keystone genus of beneficial gut flora.

The flagship product is a powdered supplement delivered in a single-scoop format that combines HMOs with lactoferrin and other human milk bioactives. These compounds are recognized by the body as native, bypassing immune defense mechanisms and reaching the gut in a fully active state. The formulation is designed to address multiple dimensions of digestive health simultaneously: selective prebiotic feeding, gut barrier repair via tight junction reinforcement, pathogen inhibition through a decoy mechanism, motility and transit regulation, immune signaling modulation, inflammation control, and gut-brain axis support.

kepos is clinician-endorsed, with over 500 healthcare professionals — spanning gastroenterology, internal medicine, and pediatrics — recommending the product to patients through the FrontrowMD platform without compensation. The product carries HSA/FSA eligibility, indicating recognition as a qualified medical expense. To date, the company reports having delivered over one million doses since launch and holds a 4.8-star product rating based on more than 350 reviews from individuals with documented digestive conditions.

The company was co-founded by Oliver, who experienced a nine-year battle with Irritable Bowel Syndrome, and Catalina, a mechanobiology researcher. Their academic partnership with the University of Chicago — an institution with over 100 Nobel laureates — underpins the scientific rigor behind the formulation. kepos positions itself as a premium, science-backed alternative to the fragmented and often ineffective digestive supplement market, emphasizing ingredient efficacy, clinical validation, and human-centric nutritional science. All products are made in the USA.